Miscarriage risk associated with couples’ pre-pregnancy caffeine consumption

A woman is more likely to miscarry if she and her partner drink more than two caffeinated beverages a day during the weeks leading up to conception, according to a new study from researchers at the National Institutes of Health and Ohio State University, Columbus. Similarly, women who drank more than two daily caffeinated beverages during the first seven weeks of pregnancy were also more likely to miscarry.

However, women who took a daily multivitamin before conception and through early pregnancy were less likely to miscarry than women who did not. The study was published online in Fertility and Sterility.

ÔÇ£Our findings provide useful information for couples who are planning a pregnancy and who would like to minimize their risk for early pregnancy loss,ÔÇØ said the study’s first author, Germaine Buck Louis, Ph.D., director of the Division of Intramural Population Health Research at NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development.

The researchers analyzed data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study, which was established to examine the relationship between fertility, lifestyle and exposure to environmental chemicals. The LIFE Study enrolled 501 couples from four counties in Michigan and 12 counties in Texas, from 2005 to 2009.

For the current study, researchers compared such lifestyle factors as cigarette use, caffeinated beverage consumption and multivitamin use among 344 couples with a singleton pregnancy from the weeks before they conceived through the seventh week of pregnancy.

The researchers reported their results using a statistical concept known as a hazard ratio, which estimates the chances of a particular health outcome occurring during the study time frame. For example, the researchers evaluated caffeinated beverage consumption in terms of the daily likelihood of pregnancy loss over a given time period. A score greater than 1 indicates an increased risk for pregnancy loss each day following conception, and a score less than 1 indicates a reduced daily risk.

Of the 344 pregnancies, 98 ended in miscarriage, or 28 percent. For the preconception period, miscarriage was associated with female age of 35 or above, for a hazard ratio of 1.96 (nearly twice the miscarriage risk of younger women). The study was not designed to conclusively prove cause and effect. The study authors cited possible explanations for the higher risk, including advanced age of sperm and egg in older couples or cumulative exposure to substances in the environment, which could be expected to increase as people age.

Both male and female consumption of more than two caffeinated beverages a day also was associated with an increased hazard ratio: 1.74 for females and 1.73 for males. Earlier studies, the authors noted, have documented increased pregnancy loss associated with caffeine consumption in early pregnancy. However, those studies could not rule out whether caffeine consumption contributed to pregnancy loss or was a sign of an unhealthy pregnancy. It’s possible, the authors wrote, that these earlier findings could have been the result of a healthy pregnancy, rather than caffeine consumption interfering with pregnancy. For example, the increase in food aversions and vomiting associated with a healthy pregnancy led the women to give up caffeinated beverages.

Because their study found caffeine consumption before pregnancy was associated with a higher risk of miscarriage, it’s more likely that caffeinated beverage consumption during this time directly contributes to pregnancy loss.

ÔÇ£Our findings also indicate that the male partner matters, too,ÔÇØ Dr. Buck Louis said. ÔÇ£Male preconception consumption of caffeinated beverages was just as strongly associated with pregnancy loss as females’.ÔÇØ

Finally, the researchers saw a reduction in miscarriage risk for women who took a daily multivitamin. During the preconception period, researchers found a hazard ratio of 0.45 ÔÇö a 55-percent reduction in risk for pregnancy loss. Women who continued to take the vitamins through early pregnancy had a hazard ratio of 0.21, or a risk reduction of 79 percent. The authors cited other studies that found that┬ávitamin B6┬áand┬áfolic acidÔÇö included in preconception and pregnancy vitamin formulations ÔÇö can reduce miscarriage risk. Folic acid supplements are┬árecommended┬áfor women of childbearing age, as their use in the weeks leading up to and following conception reduces the risk for having a child with a┬áneural tube defect.

The U.S. Centers for Disease Control and Prevention offer information on the steps men and women of reproductive age can take to help ensure they have a healthy baby-whether they are planning pregnancy or not.

Source

Couples’ pre-pregnancy caffeine consumption linked to miscarriage risk.. NIH News, March 24, 2016.

2,061 thoughts on “Miscarriage risk associated with couples’ pre-pregnancy caffeine consumption”

  1. Heya! I just wanted to ask if you ever have any issues with hackers?
    My last blog (wordpress) was hacked and I ended up losing many months of hard work due to no data backup.
    Do you have any methods to prevent hackers?

  2. I do not know if it’s just me or if everyone else encountering problems with your blog. It looks like some of the written text within your content are running off the screen. Can someone else please provide feedback and let me know if this is happening to them as well? This might be a issue with my web browser because I’ve had this happen previously. Kudos

  3. Decide on this matter so that you will be able to move the table to the scope.. So, if you stay in any part of the World and due to any reason wont be able to participate the grand festivities in home, send gifts to India through this trusted e-gifting portal. That your Kindle?April 6, 2014 at 1:46 PM TweetLeather has become a popular collection for making handbags for a long, long time.Make the learning fun, experiential and encourage participation and input from every person.
    Cheap NFL Jerseys China

  4. They learn nearby clear-cut body image, good nutrition, and devices to put a stop to hurt.”What does that mean for the smaller application developers and “content licensees” providing content purchased from the “actual” content providers such as TSN? Charles says that although smaller companies may be able to survive in a “niche” market, they will not be able to compete with the Yahoos, ESPNs and TSNs of the world. “When you have what (European competitors) do not have … for example, the interests in the NFL, NBA, and world coverage that we have – Olympics, soccer, tennis, golf, Formula One, boxing and a list much too long to detail here, then we have entry,” says Charles, “that allows TSN to become much more entrenched in that market, wherever it may be, in 2011.Our body can count high on health ter by eating less.We have a suggesting where I e from, “nothing is hard for the one who knows how. Mercury – the intellectual pla however needs to be strong. This eliminates the work of writing a examine in your bills and having to attend for them to be mailed out.A community akin to 6,000 rectangle yards for Japanese People Pavilion the result quite large “untruthful silkworm,” released on the planet detox rose hence is its “Silkworm Purple Colours Island” with Chinese Language Program moniker. This is where dance oes co in.At present, all key U.
    Cheap NFL Jerseys China

  5. Õè│Õè¿Õèøµêɵ£¼ÕÀ▓þ╗ÅÕñºÕ╣àÕ║ªõ©èÕìçÒÇéþ¡ëÕ¥à5ÕêåÚƃÕÉÄ´╝î5µ»½Õàï/ÕìâÕàï´╝îÕÉîµ»öÕó×Úò┐3.õ¢åµÿ»ÚóäÕàêµÇºþÜäÞ«¥þ¢«ÕÆîµØíõ╗ÂÕ╝ÅþÜäÕÅìÕ║öÕ«îÕ࿵ÿ»õ©ñÕø×õ║ïÕøáõ©║þø«Õëìþöƒþî¬Õ¡ÿµáÅÕ░ÜÕ£¿Ú½ÿõ¢ì´╝îÞ┐Öþé╣ÚÆ▒Þâ¢Õ╣▓õ╗Çõ╣ê´╝ƒÞÇîõ©öµ»ÅÕ╣┤Þ┐ÿÕæê15%´¢×20%þÜäÞÂïÕè┐Õ£¿Õó×Úò┐´╝î2þé╣ÚƃÞÁÂÕê░þÜäµùÂÕÇÖ´╝îÞ«░ÞÇàõ║åÞºúÕê░ÒÇé

  6. The use of coupons is getting more and more popular these days. There are “coupon queens”, Internet sites and television shows that all claim to have gotten things for free because of their couponing. They make it sound so easy but it does take a bit of effort and organization. The tips in this article can provide you with the secrets of couponing so you are able to secure your own savings.
    Yeezy Boost 350 for sale

  7. Pain-Body Work: The more you repress this negative self, the darker and denser it becomes. Nothing terrible may result to you when we get a reading; inside truth, we will even receive hold of the great deal of superior points from it.One of the best ways on how to prevent and slow the aging process is by being happy..So, surprise your dear ones this festive season with amazing gifts.
    Cheap NFL Jerseys Wholesale

  8. There are so very quіtе several fabulous handbags tо adore enjoy with. The Signature handbags аrе constantly terrific tо private whеn want а bag to opt for аlmoѕt that. Also, the Hobo bags аrе terrific for any event. The Shopper handbag is the ideal software for people they like to carry larger containers. The smaller bags are whаt have tо have for out there on the town and for people who dо not treatment for the bulkier bags likе thе substantial Shoulder handbags.

  9. Thank you for any other informative web site. Where else could I am getting that type of information written in such an ideal method?
    I have a venture that I’m simply now operating on, and I have been on the look out for such information.

  10. Marinate it or season it with salt, pepper and lemon juice.

    You may be having a large gathering with friends or a simple meal with your family, either one
    your fire pit can be a great way to add uniqueness to your meal.
    Two slices of pimento filled olives make great snake
    eyes and a sliver of red pimento for a tongue.

  11. Paddling around the village, observing the life of
    people who live every day in the floating village was an experience I can’t describe with words alone.
    Tuan Chau food area is also a suitable choice to have lunch
    without moving much, you can enjoy various dishes from 7
    usd per person. Online booking – Booking the trip directly
    with the cruiser via official website is more expensive
    than you book through an online travel agent, this is a normal practice in Vietnam tourism industry as
    the cruise companies usually offer a better price for travel
    agents.